Gut Hormones (Gastrin, Glucagon, VIP, PP)
Chemical Pathology
Notes
Gut hormone levels are indicated in the investigation of patients with symptoms suggestive of a neuroendocrine tumour or for screening of patients with multiple endocrine neoplasia type I.
The profile includes the following gut hormones:
- Gastrin
- Glucagon
- Pancreatic polypeptide
- Vasoactive intestinal polypeptide
- Somatostatin
- Chromogranin A and B
CART (cocaine- and amphetamine related transcript) is no longer form part of the routine profile but is available in certain circumstances - please contact the Duty Biochemist if considered necessary.
Sample requirements
Patient preparation
The patient should have fasted for at least 6-8 hours prior to sampling.
Please list ALL current medication taken by the patient at the time of sampling. Please note problems with:
(i) Proton Pump Inhibitors: Omeprazole (Losec), Lansoprazole, Pantoprazole
If the patient is currently receiving Omeprazole therapy, Zollinger Ellison syndrome (ZES) cannot be diagnosed. This treatment has to stop for TWO WEEKS before submitting a fasting sample for assay.
(ii) H2 Antagonists: Ranitidine, Cimetidine, Famotidine, Nizatidine
When a gastrinoma is first suspected, it is at the discretion of the clinician whether or not to take the patient off treatment before testing for Gastrin. Should a fasting sample show a borderline or high level, it may be necessary to cease medication for 72 hours before repeating the screen.
Sample requirements
For adults 2 x 4mL pre-chilled EDTA tubes on ICE
Storage/transport
Do not store. Send immediately to the laboratory on ICE as the sample must be separated and plasma frozen within 15 minutes.
Required information
Relevant clinical details including current medication.
Turnaround times
Samples are sent to a referral laboratory for analysis, with results expected back within four weeks.
Reference ranges
Hormone | Reference Range | Units |
---|---|---|
Gastrin | <40 | pmol/L |
Glucagon | <50 | pmol/L |
PNCP (pancreatic polypeptide) | <300 | pmol/L |
VIP (vasoactive intestinal polypeptide) | <30 | pmol/L |
Somatostatin | <150 | pmol/L |
Chromogranin A | <60 | pmol/L |
Chromogranin B | <150 | pmol/L |
Page last updated 15/03/2024