Anti-DNA Antibodies (dsDNA)

Department of Immunology

Notes

• Double stranded DNA antibodies are found in 70-90% of patients with SLE (systemic lupus erythematosus) and tend to correlate with disease activity. A negative result does not rule out the diagnosis of SLE.
• Raised levels may also be seen in a small minority of patients with chronic active hepatitis.
• Performed automatically after a positive ANA result.

Sample Requirements

Clotted blood. (No patient preparation or special handling required)

Adult

5ml Gold-top SST tube or 3.5ml Rust-top gel tube (Trust users only)

Paediatric

1ml serum Sample

Time limit for add-on

3 days

Turnaround Times

10 days

Reference Range

Negative <10 IU/ml

Equivocal 10-15 IU/ml

Positive >15 IU/ml