Treatment Guidelines

• Andexanet alfa (Ondexxya®) for reversing rivaroxaban or apixaban in acute, life-threatening G.I. bleeds
• Ciclosporin for acute severe Ulcerative Colitis
• Hepatitis B prophylaxis is adults taking immunosuppressive therapy
• High Output Stoma
• Inflammatory Bowel Disease (IBD) Biologics Pathway
• Infliximab
• Laxative Guideline
• Proton Pump Inhibitors (PPI) - Oral
• Proton Pump Inhibitors (PPI) - Intravenous
• Terlipressin for variceal bleeding / hepato-renal syndrome

• Acute Coronary Syndrome (ACS)
• ACS Antiplatelets Guideline
• Adenosine infusion (for Fractional Flow Reserve testing)
• Amiodarone
• Andexanet alfa (Ondexxya®) for reversing apixaban, edoxaban, or rivaroxaban or in acute, life-threatening G.I. bleeds
• Anticoagulants (oral) - management of bleeding
• Anticoagulants – switching
• Antiplatelets
• Cancer Associated Thrombosis
• Contrast-induced Nephropathy Prophylaxis
• DC cardioversion for AF on CCU
• Digoxin - being updated
• Digoxin overdose - DigiFab
• DOAC elective surgery guideline
• DOAC choice
• DOAC reversal for acute, life-threatening bleeds
• DOBUTamine infusion
• DOPamine infusion
• Enoxaparin (Inhixa) - VTE Prophylaxis
• Enoxaparin (Inhixa) - VTE Treatment
• Fluid Resuscitation - intranet
• Fondaparinux
• GTN infusion chart
• HbA1c testing and glucose control in ACS
• Heparin (unfractionated) infusion
• Idarucizumab (Praxbind®) for reversing dabigatran in acute, life-threatening bleeds
• Iloprost for Critical Ischaemia or Severe Raynaud’s Phenomenon - intranet
• Inclisiran
• Labetalol infusion chart - intranet
• Lipid Pathway (primary prevention)
• Lipid Pathway (secondary prevention)
• Lipid Pathway (summary of national guidance)
• Nicardipine i.v. infusion guideline (adult critical care)
• Noradrenaline (peripheral infusion)
• Orthostatic Hypotension management
• Post-Carotid Endarterectomy Hypertension management
• Prasugrel
• Thrombolysis of Massive Pulmonary Embolus (PE) - intranet
• Thrombolysis of STEMI (contingency 2020)
• Ticagrelor
• Tirofiban
• VTE Prophylaxis - Enoxaparin (Inhixa) Dosing Guideline
• VTE Treatment - Enoxaparin (Inhixa) Dosing Guideline
• Warfarin Initiation
• Warfarin 'Bridging' Protocol (DALTEPARIN) for elective procedures
• Warfarin 'Bridging' Protocol (ENOXAPARIN) for elective procedures (non-pregnant adults)
• Warfarin: Management of high INR or bleeding

• Aminophylline Infusion Chart
• Asthma inhaler guideline
• COPD inhaler guideline
• Intrapleural Fibrinolytics for Pleural Infection (alteplase & dornase alfa)
• Pulmonary Embolism - intranet
• Thrombolysis of Massive Pulmonary Embolus (PE) - intranet
• Non-Invasive Ventilation for Acute Hypercapnic Respiratory Failure - intranet
• High Flow Nasal Oxygen - intranet
• Tuberculosis screening for Biologic and Immunomodulatory drugs for inflammatory conditions

• ADHD Medication Supply Shortage
• Alcohol Detoxification - intranet
• Apomorphine in Parkinson's Disease
• Dementia agitation pathway - G-Care
• Domperidone - MHRA restrictions
• Emergency Sedation (formerly Rapid Tranquillisation) - intranet
• Ketamine (multimodal analgesia) - intranet
• MAOI Diet Restrictions Advice
• Morphine Allergy - Pain Treatment - intranet
• Naloxone - intranet
• Neuropathic Pain - being updated
• Nicotine Replacement Therapy (NRT) - inpatients (non-pregnant)
• Nicotine Replacement Therapy (NRT) - inpatients (pregnant)
• Opioid Equivalence Chart
• Management of Opioid Users (inpatients) - intranet
• Pain Formulary
• Paracetamol (i.v.) prescribing criteria
• Paracetamol: Weight-adjusted dosing (adults)
• Parkinson's Disease - Medicines Management in Inpatients
• Post-operative Nausea & Vomiting (PONV) - intranet
• Status Epilepticus - intranet

• Antibiotic Guidelines
• MRSA Guideline (GHNHSFT) - intranet
• Splenectomy - intranet

• Adrenal incidental tumour (incidentaloma) pathway
• Diabetic Ketoacidosis - intranet
• Hypoglycaemia - intranet
• Insulin Formulary
• Insulin Substitution
• Peri-operative Diabetes Management - intranet
• Corticosteroid Perioperative Management
• Corticosteroid Withdrawal
• Osteoporosis Guideline
• Short Synacthen Test

• Erectile Dysfunction

• Anaemia and Iron Deficiency in Oncology Patients
• Bone Protection in High Grade Lymphoma
• Cancer Associated Thrombosis
• Capecitabine / 5FU Diarrhoea
• Cytokine Release Syndrome Treatment Guideline
• Darbepoetin Alfa for anaemia in patients receiving chemotherapy
• Anaemia and Iron Deficiency in Oncology Patients
• Glucarpidase for methotrexate-induced renal dysfunction
• Glycaemic Control in Cancer Patients
• Haemophagocytic Lymphohistiocytosis (HLH)
• Hypoadrenalism (Oncology IO Hypoadrenalism Pathway)
• ICANS (Immune Cell Associated Neurotoxicity Syndrome) Guideline
• Immune-related Diarrhoea & Colitis
• Initial management of suspected acute promyelocytic leukaemia
• Methylthioninium chloride (Proveblue) for ifosfamide induced encephalopathy [previously known as 'methylene blue']
• Management of Immune-related Adverse Events (IrAEs) Caused by immunotherapy
• Management of Skin Toxicity Related to Parenteral Anti-EGFR Treatment for Colorectal Cancer
• Mosunetuzumab Treatment Guideline
• Tebentafusp for the Treatment of Metastatic Uveal Melanoma in HLA-A*02:01 Positive Patients
• Tumour Lysis Syndrome - intranet
• Prescription & Monitoring of High Dose Corticosteroids in Oncology Inpatients

• Hypercalcaemia (tumour-induced)
• Hypocalcaemia
• Hyperkalaemia
• Hypokalaemia
• Hypomagnesaemia
• Hyponatraemia
• Hypophosphataemia
• Cosmofer® (iron dextran) total dose infusion guideline
• Cosmofer® (iron dextran) administration - see Medusa or sample drug chart
• Diafer® (iron isomaltose) administration - see Medusa
• Ferinject® (ferric carboxymaltose) administration - see Medusa or sample drug chart
• Monofer® (iron[III] isomaltoside 1000) administration - see Medusa or sample drug chart
• Feraccru® (ferric maltol)
• Preoperative management of anaemia
• Anaemia and Iron Deficiency in Oncology Patients
• Vitamin B12 deficiency treatment
• Vitamin D prescribing guidance - Primary Care
• Vitamin D prescribing guidance - Secondary Care
• Vitamin D Rapid Loading: Bone Health Specialist Protocol - Inpatient use only
• Vitamins / Minerals Policy
• Pabrinex Shortage
• Intravenous Fluid Management – intranet
• Plerixafor - stem cell mobilisation
• Unblocking Enteral Feeding Tubes

• Abatacept
• Infliximab
• Tocilizumab
• Perioperative Biologic Guideline
• Psoriatic Arthritis Biologic Pathway
• Moderate Rheumatoid Arthritis Biologic Pathway
• Severe Rheumatoid Arthritis Biologic Pathway
• Axial Spondyloarthritis (Ankylosing Spondylitis) and Non-Radiographic Axial Spondyloarthritis Biologic Pathway

Dry Eye Treatment

• Mouthcare Guideline - intranet

• Atopic Dermatitis Biologic Pathway
• Emollient Formulary
• Potassium Permanganate - intranet
• Psoriasis Biologic Pathway
• Psoriatic Arthritis Biologic Pathway
• Infliximab
• Infliximab for Pyoderma Gangrenosum
• Stevens-Johnson Syndrome & Toxic Epidermal Necrolysis

• Anaesthesia for Fractured Neck of Femur
• Peri-operative medicines management

• Blood Transfusion Policy (intranet)
• Management of Major Haemorrhage SOP – including Action Cards for ACRT, Porters, Site Team and Emergency Theatre Co-ordinator
• Running a ROTEM
• ROTEM interpretation algorithm (obstetrics)
• ROTEM interpretation algorithm (non-obstetrics)
• Transfusion Reactions (intranet)
• Special requirements for transfusion (intranet)
• Direct Oral Anticoagulant (DOAC) Reversal guideline
• Human Prothrombin Complex Concentrate (PCC) guidance (Octaplex®)
• Patients who refuse blood and blood components

• Anticholinergic Burden Tool
• Creatinine Clearance Calculator
• Drugs of Animal Origin
• Emergency Drug Dose Cards
• End of Life Care - Prescribing Guidance
• Emergency Department adult guidelines (intranet)
• Emergency Department paediatric guidelines (intranet)
• Emergency Department Antidotes List
• Frailty Prescribing Guidance
• Paediatric Department Guidelines (intranet)
• Unblocking Enteral Feeding Tubes

Digital ReSPECT SOPs and Action Cards - Advance Care Planning